MCM8- AND MCM9 DEFICIENCIES CAUSE LIFELONG INCREASED HEMATOPOIETIC DNA DAMAGE DRIVING P53-DEPENDENT MYELOID TUMORS

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Summary: Hematopoiesis is particularly sensitive to DNA damage.Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy.It is not known why hematopoietic cells are highly vulnerable to DNA damage.Addressing this question is complicated by the paucity of mouse models of hematopoietic malignancies due to defective

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Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity

IntroductionRepetitive transcranial magnetic stimulation (rTMS) is a widely used therapeutic tool in neurology and psychiatry, but its cellular and molecular mechanisms are not fully understood.Standardizing stimulus parameters, specifically electric field strength, is crucial in experimental and clinical settings.It enables meaningful comparisons

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